Ongoing Projects

  • New cognitive protection strategy to treat epilepsy by preventing the impact of TrkB-FL-mediated cleavage

    Funding Entity: Fundação para a Ciência e Tecnologia

    Role: Principal Investigator (FMUL)
    2025-2028

  • Pan-European Network for Neuroscience Research Infrastructure and Strengthening of Support capacities

    Funding Entity: HORIZON Europe, HORIZON-WIDERA-2023-ACCESS-04-01 - Pathways to Synergies, Coordination and Support Action

    Consortium involving Faculdade de Medicina da Universidade de Lisboa and Instituto de Medicina Molecular Joao Lobo Antunes (Portugal), Instytut Farmakologii Im. Jerzego Maja Polskiej Akademii Nauk (Poland), The Fundación de Recerca Clínic Barcelona, Institut d’Investigacions Biomèdiques August Pi i Sunyer (Spain), and Vilnius University Life Sciences Center (Lithuania).
    Role: Member (GIMM)
    2024-2026

  • Pacto de Inovação “HfPT – Health from Portugal [Componente 5 do Plano de Recuperação e Resiliência, ao abrigo do concurso no. 02/C05-i01/2022]

    Funding Entity: Plano de Recuperação e Resiliência
    Role: Principal Investigator (GIMM)
    2022-2025

  • TAT-TrkB, a novel neuroprotective compound to fight Alzheimer´s disease

    Funding Entity: Santa Casa da Misericórdia
    Reference: MB35–2021
    Role: Principal Investigator (GIMM)
    2021-2025

Past Projects

  • Epileptogenesis & Epilepsy Network

    Funding Entity: European Union’s Horizon 2020 research and innovation programme under grant agreement No 952455.

    Consortium involving Instituto de Medicina Molecular João Lobo Antunes (iMM), Lisboa, Portugal; Amsterdam Medical Center University of Amsterdam, The Netherlands; Sapienza University of Rome, Italy; University of Lund, Sweeden
    Role: Member (GIMM)
    2020-2023

  • Novel Therapeutic Strategy and New Biomarker for Alzheimer's disease Based on BDNF Receptor Cleavage

    Funding Entity: Santa Casa da Misericórdia
    Reference: MB37–2017
    Role: Principal Investigator (GIMM)
    2017-2020

  • Astrosomes: artificial astrocytes as a novel approach to regulate neuronal communication.

    Funding Entity: Fundação para a Ciência e Tecnologia
    Reference: PTDC/BTM-SAL/32147/2017
    Role: Co-PI (PI: Sandra H. Vaz) (GIMM)

  • Adenosine levels reestablishment: new approach for the treatment of Rett Syndrome

    Funding Entity: Fundação para a Ciência e Tecnologia
    Reference: PTDC/MED-NEU/31929/2017
    Role: Coordenator

  • CYP46A1 as a new therapeutic target in Niemann-Pick type C disease

    Funding Entity: Fundação para a Ciência e Tecnologia
    Reference: PTDC/MED-NEU/29455/2017
    Role: Researcher (PI: Elsa Rodrigues)

  • Regulation of adenosine levels as a new therapeutic strategy for Rett Syndrome

    Funding Entity: Association Française du Syndrome de Rett
    Role: Coordinator (GIMM)

  • Neurologic and Psychiatric Disorders: from synapses to networks (Synanet)

    Funding Entity: European Commission, Horizon 2020, Call H2020-TWINN-2015 / H2020-TWINN-2015 - Twinning

    Aims to promote collaborative multidisciplinary and translational research by enhancing effective knowledge transfer, exchange of best research practices, and the mobility of early stage researchers between the Instituto de Medicina Molecular (IMM) at the University of Lisbon, the University of Eastern Finland, the University of Rome La Sapienza, and the Lancaster University at UK.
    Role: Member (GIMM)
    2016-2019

  • Adenosine receptors: new pharmacological targets for the treatment of Rett syndrome.

    Funding Entity: Fundação para a Ciência e Tecnologia
    Reference: EXPL/BIM-MEC/0009/2013
    Role: Coordinator

  • Brain Gut interaction- neurotrophic actions

    Funding Entity: Nestlé Research Center
    Reference: Nestec/IMM/474/2008
    Role: Investigator

  • Unraveling the effect of different Abeta species upon hippocampal synaptic plasticity and the neuroprotective role of BDNF

    Funding Entity: Bayer
    Role: Coordinator

  • Role of TrkB receptors in ageing

    Funding Entity: Gulbenkian Foundation
    Role: Co-coordinator

  • Purines and control of astrocytes-neurons signalling in rat hippocampal slices and cultured cells

    Funding Entity: Fundação para Ciência e Tecnologia
    Reference: SFRH/BD/12167/2003
    Role: Investigator

  • Neurophysiological mechanisms of aging: novel view of old concepts

    Funding Entity: Bial Foundation
    Reference: PROJ. 57/12
    Role: Coordinator

  • Study of cytochrome c release induced by Billirubine, Amyloid b-peptide, and Glycochenodeoxycholate

    Funding Entity: Fundação para a Ciência e Tecnologia
    Reference: PRAXIS/C/SAU/14311/1998
    Role: Investigator

Intellectual Property

Trkb-fl based polypeptides and their use in the treatment of alzheimer's disease

Inventor: Maria José de Oliveira Diógenes Nogueira, João Filipe Fonseca Gomes, André Jerónimo Santos, Ana Maria Ferreira de Sousa Sebastião, Carlos Bandeira Duarte

Current Assignee: Faculdade de Medicina da Universidade de Lisboa, Fundação GIMM Gulbenkian Institute For Molecular Medicine, Universidade de Coimbra

Worldwide Application: US (US20230321189A1), CA (CA3177866A1), JP (JP2023521071A), AU (AU2021248268A1), European Patent Office (EP4125999B1)

Classification: A61K38/1787 - Receptors; Cell surface antigens; Cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor; A61P25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia